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The stack

4 picks · curated
02
Hacker News txt 70 c · 123 pts

The AI cost of JavaScript frameworks

Nolan Lawson had Claude Code build the same Pokémon app five times in each of a dozen frameworks and measured cost, time, tokens, and Lighthouse scores. Hono+htmx, Astro, and Nuxt came out cheapest; SvelteKit, Gracile+Lit, and Angular cost the most, and plain Vite with no framework did worse than several frameworks.

03
Hacker News txt 398 c · 1479 pts

HackerTube: YouTube built from videos recommended by HN

Tired of YouTube's recommendation slop, Andrej Karpathy had Opus 5.5 mine every Hacker News comment for video recommendations and ship hackertube.org in about two hours: 6,454 videos drawn from 40K comments, 2007–2026, with account-free recommendations stored in the browser.

04
NPR txt today · Sydney Lupkin

How one family gave a critical boost to gene therapy research

After their daughter Eliza was diagnosed with Sanfilippo syndrome in 2013, the O'Neill family raised millions for early research on a gene therapy. Ultragenyx carried it forward, and the FDA approved it in September as Fayuvi, a one-time infusion priced at nearly $4 million that works best in the youngest patients.